P-314 PlasmaShotting: a new method of treating “thin” endometrium

Abstract Study question Is a new method of subendometrial platelet-rich plasma (PRP) injection (PlasmaShotting) effective in patients with “thin” endometrium? Summary answer PlasmaShotting showed higher efficiency the group endometrium compared to conventional intrauterine infusion What is known already The problem one urgent challenges modern reproductive medicine. In suffering from this condition, there decrease pregnancy rate and an increase miscarriage rates. “Thin” less than 7 mm according ultrasound. To correct many methods have been proposed: hormone replacement therapy high doses estrogens, aspirin, GnRH agonists, vitamin E, pentoxifylline, sildenafil, colony-stimulating factors (G-CSF) PRP, but none proposed has shown enough effectiveness. design, size, duration evaluate effectiveness we organized study that included 72 people. Inclusion criteria were age 40 years, endometrial thickness 6.5 on days 8-10 therapy, 3 or more unsuccessful embryo transfers excellent quality embryos before. Participants/materials, setting, divided into 2 groups: Group 1 (23 patients) underwent hysteroscopy submucosal injections (PRP - PlasmaShotting) 10-12 cycle. (49 cycle Main results role chance clinical was 47.8% (n = 11), 34.6% 17). live births 34.7% 8), 20.4% 10). 13.1% 3), 14.2% 7) Limitations, reasons for caution research should be continued Wider implications findings as treating can used who can't achieve Trial registration number not applicable